Parasite Load Decrease during Application of a Safe and Easily Applied Antileishmanial Aminoglycoside Cream
نویسندگان
چکیده
1 Institut Pasteur de Tunis, Tunis, Tunisia, 2 Regional Hospital of Gafsa, Gafsa, Tunisia, 3 United States Army Medical Materiel Development Activity, Fort Detrick, Maryland, United States of America, 4 Fast-Track Drugs & Biologics, LLC, North Potomac, Maryland, United States of America, 5 Assistance Publique Hôpitaux de Paris, Paris, France, 6 Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
منابع مشابه
Optimization of Topical Therapy for Leishmania major Localized Cutaneous Leishmaniasis Using a Reliable C57BL/6 Model
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Leishmaniasis is a neglected public health problem caused by the protozoan species belonging to the genus Leishmania affecting mostly the poor populations of developing countries. The causative organism is transmitted by female sandflies. Cutaneous, mucocutaneous, and visceral clinical manifestations are the most frequent forms of leishmaniasis. Chemotherapy still relies on the use of pentavale...
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An antileishmanial compound, 14-deoxy-11-oxo-andrographolide, a derivative of andrographlide, isolated from the Indian medicinal plant Andrographis paniculata was evaluated for efficacy in free form and in different vesicular delivery modes on hamster model of Leishmaniasis. The subcutaneous injection of free drug reduced the spleen parasite load by 39%, whereas for drug incorporated in liposom...
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The roles of interleukin-4 (IL-4) and IL-13 in the regulation of immunity to Leishmania donovani infection are still poorly understood. Here we show that the increased parasite load observed in IL-4(-/-) and IL-4 receptor alpha(-/-) mice correlates with retarded granuloma maturation and antileishmanial activity and that the increased parasite load observed in IL-4 receptor alpha(-/-) mice corre...
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